SKIN AND SOFT TISSUE INFECTIONS: Edited by Matteo BassettiRecent concepts in fungal involvement in skin and soft tissue infectionsPeghin, Maddalenaa; Ruiz-Camps, Isabelb Author Information aInfectious Diseases Division, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy bInfectious Diseases Department, Hospital Universitario Vall de Hebrón, Universidad Autónoma de Barcelona, Barcelona, Spain Correspondence to Maddalena Peghin, MD, PhD, Clinica di Malattie Infettive, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Presidio Ospedaliero Universitario Santa Maria della Misericordia, Piazzale Santa Maria della Misericordia 15, Udine 33010, Italy. Tel: +39 0432555350; e-mail: [email protected] Current Opinion in Infectious Diseases 35(2):p 103-111, April 2022. | DOI: 10.1097/QCO.0000000000000806 Buy Metrics Abstract As the at-risk population expands and new antifungal resistance patterns develop, it is critical to understand and recognize cutaneous manifestations of old and emerging fungal diseases. Purpose of review The aim of this review is to provide an overview of the most frequent and emerging deep cutaneous fungal infections following either primary inoculation or secondary spread after haematogenous seeding in disseminated infections in different geographical areas. Recent findings Fungal skin and soft tissue infections (SSTIs) encompass a variety of pathological conditions based on the site of the infection, route of acquisition of the pathogen, epidemiological setting and the virulence of the fungus in relation to the host. The approach to a patient suspected of having a fungal SSTI is complex and usually poses a major diagnostic challenge. The treatment approach should include attempts at immune reconstitution, targeted antifungal therapy and/or aggressive surgical debridement. Summary Fungal SSTIs can be an important cause of morbidity and mortality in both immunocompromised and immunocompetent patients and are being reported with increasing frequency worldwide. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.