TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina M. CoyleZoonoses and global epidemicsJudson, Seth D.a; Rabinowitz, Peter M.a,bAuthor Information aDepartment of Medicine bDepartment of Environmental and Occupational Health Sciences, Department of Global Health, University of Washington, Seattle, Washington, USA Correspondence to Peter M. Rabinowitz, MD, MPH, Department of Environmental and Occupational Health Sciences, Department of Global Health, University of Washington, Seattle, WA 98195, USA. Tel: +1 206 616 0598; e-mail: [email protected] Current Opinion in Infectious Diseases: October 2021 - Volume 34 - Issue 5 - p 385-392 doi: 10.1097/QCO.0000000000000749 Buy Metrics Abstract Purpose of review The purpose of the review is to summarize recent advances in understanding the origins, drivers and clinical context of zoonotic disease epidemics and pandemics. In addition, we aimed to highlight the role of clinicians in identifying sentinel cases of zoonotic disease outbreaks. Recent findings The majority of emerging infectious disease events over recent decades, including the COVID-19 pandemic, have been caused by zoonotic viruses and bacteria. In particular, coronaviruses, haemorrhagic fever viruses, arboviruses and influenza A viruses have caused significant epidemics globally. There have been recent advances in understanding the origins and drivers of zoonotic epidemics, yet there are gaps in diagnostic capacity and clinical training about zoonoses. Summary Identifying the origins of zoonotic pathogens, understanding factors influencing disease transmission and improving the diagnostic capacity of clinicians will be crucial to early detection and prevention of further epidemics of zoonoses. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.