GASTROINTESTINAL INFECTIONS: Edited by James A. Platts-MillsShigellosis in young children in low-income and middle-income countries: insights from molecular diagnosticsPlatts-Mills, James A.; Rogawski McQuade, Elizabeth T. Author Information Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, Virginia, USA Correspondence to James A. Platts-Mills, MD, Division of Infectious Diseases and International Health, University of Virginia, PO Box 801340, Charlottesville, VA 22908-1340, USA. Tel: +1 434 243 8997; e-mail: [email protected] Current Opinion in Infectious Diseases: October 2021 - Volume 34 - Issue 5 - p 463-470 doi: 10.1097/QCO.0000000000000758 Buy Metrics Abstract Purpose of review To describe the impact of molecular diagnostics on our understanding of the burden and epidemiology of shigellosis in children in low-income and middle-income countries. Recent findings The incorporation of molecular diagnostics has led to a substantial increase in estimates of the burden of shigellosis and have allowed for further resolution of other aspects of Shigella epidemiology, including the clinical characteristics of shigellosis, the association between clinical and subclinical Shigella infection and linear growth shortfalls, protection after natural infection, duration of convalescent shedding, and host determinants of susceptibility. Summary The increased sensitivity and precision afforded by molecular approaches has represented a major advance in our understanding of the epidemiology and burden of shigellosis in the settings of highest importance. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.