TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina M. CoyleSubarachnoid neurocysticercosis: emerging concepts and treatmentNash, Theodore E.; O’Connell, Elise M.Author Information Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA Correspondence to Theodore E. Nash, MD, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, 40 Clubside Drive, Asheville, N.C. 28804;. e-mail: [email protected] Current Opinion in Infectious Diseases: October 2020 - Volume 33 - Issue 5 - p 339-346 doi: 10.1097/QCO.0000000000000669 Buy Metrics Abstract Purpose of review Subarachnoid neurocysticercosis (SUBNCC) is caused by a morphologically unique proliferative form of Taenia solium involving the subarachnoid spaces. Prolonged therapy based upon the pathophysiology of SUBNCC and long-term follow-up have shed light on the course of disease and led to highly improved outcomes. Recent findings SUBNCC has a prolonged incubation period of between 10 and 25 years characterized by cyst proliferation and growth and invasion of contiguous spaces leading to mass effect (Stage 1). With induction of the host-immune responses, cysts degenerate leading to a predominately inflammatory arachnoiditis (Stage 2) causing hydrocephalus, infarcts, and other inflammatory based neurological manifestations. Inactive disease (Stage 3) may occur naturally but mostly is a result of successful treatment, which generally requires prolonged intensive anthelminthic and antiinflammatory treatments. Cerebral spinal fluid cestode antigen or cestode DNA falling to nondetectable levels predicts effective treatment. Prolonged treatment with extended follow-up has resulted in moderate disability and no mortality. Repeated short intensive 8–14-day courses of treatment are also used, but long-term outcomes and safety using this strategy are not reported. Summary SUBNCC gives rise to a chronic arachnoiditis. Its unique ability to proliferate and induce inflammatory responses requires long-term anthelmintic and antiinflammatory medications. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.