GASTROINTESTINAL INFECTIONS: Edited by James A. Platts-MillsSapovirus: an emerging cause of childhood diarrheaBecker-Dreps, Sylviaa; González, Fredmanb; Bucardo, FilemónbAuthor Information aDepartments of Family Medicine and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA bDepartment of Microbiology, National Autonomous University of Nicaragua, León, León, Nicaragua Correspondence to Sylvia Becker-Dreps, MD, MPH, Department of Family Medicine, University of North Carolina at Chapel Hill, 590 Manning Drive, Chapel Hill, NC 27599-7595, USA. E-mail: [email protected] Current Opinion in Infectious Diseases: October 2020 - Volume 33 - Issue 5 - p 388-397 doi: 10.1097/QCO.0000000000000671 Buy Metrics Abstract Purpose of review Sapovirus, a genus in the Caliciviridae family alongside norovirus, is increasingly recognized as an important cause of childhood diarrhea. Some challenges exist in our ability to better understand sapovirus infections, including the inability to grow sapovirus in cell culture, which has hindered diagnosis and studies of immunity. Another challenge is that individuals with sapovirus infection are commonly coinfected with other enteric pathogens, complicating our ability to attribute the diarrhea episode to a single pathogen. Recent findings Development of molecular methods for sapovirus detection has increased our ability to measure disease prevalence. The prevalence of sapovirus varies between 1 and 17% of diarrhea episodes worldwide, with the highest burden in young children and older adults. Further, epidemiological studies have used novel approaches to account for the presence of coinfections with other enteric pathogens; one multisite cohort study of children under two years of age found that sapovirus had the second-highest attributable incidence among all diarrheal pathogens studied. Summary Especially in settings where rotavirus vaccines have been introduced, efforts to reduce the overall burden of childhood diarrhea should focus on the reduction of sapovirus transmission and disease burden. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.