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Herpes simplex virus encephalitis update

Stahl, Jean Paula,b; Mailles, Alexandrac,b

Current Opinion in Infectious Diseases: June 2019 - Volume 32 - Issue 3 - p 239–243
doi: 10.1097/QCO.0000000000000554
CNS INFECTIONS: Edited by Adarsh Bhimraj

Purpose of review HSV is the most frequently identified cause of infectious encephalitis, in Western countries. This article is an update on the topic based on a review of recent studies from 2017 to 2018.

Recent findings Acyclovir is still the first line treatment, and no new drugs are currently available for clinical use. The major considerations for HSV encephalitis are as follows: point one, clinical evaluation remains the most important factor, as though CSF HSV PCR has a good sensitivity, in a small proportion of patients the initial testing might be negative. MRI brain is the first line imaging test, and mesial temporal lobe involvement and other typical findings are important for diagnosis; point 2, there should be emphasis on sequela, short-term, and long-term outcomes, and not just case fatality rated in future studies and clinical management. Auto-immune encephalitis can be triggered by HSV, and should be considered in patients who are not responding to treatment; point 3, future studies should be on better management of sequela, and better treatment regimens including those targeting the immune response.

Summary Autoimmune encephalitis is a clearly identified complication of HSV encephalitis. Inflammatory mechanisms are linked to the clinical presentation as well as severity and poor outcome. Initial corticosteroid therapy has to be evaluated in order to prevent complications.

aInfectious Diseases Department, University and Hospital Grenoble Alpes, Grenoble Cedex, France

bEuropean Study Group on Infections of the Brain (ESGIB). Basel, Switzerland

cInfectious Diseases Department, Santé Publique France, Saint Maurice Cedex, France

Correspondence to Jean Paul Stahl, Infectious Diseases Department, University and Hospital Grenoble Alpes, Grenoble Cedex, France. E-mail:

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