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Rapid diagnostic tests for defining the cause of community-acquired pneumonia

Basnayake, Thilini L.a; Waterer, Grant W.b,c

Current Opinion in Infectious Diseases: April 2015 - Volume 28 - Issue 2 - p 185–192
doi: 10.1097/QCO.0000000000000148
RESPIRATORY INFECTIONS: Edited by Michael S. Niederman

Purpose of review We review the potential new diagnostic tools for determining the cause of pneumonia in the setting of community-acquired infection after outlining the limitation of currently available tests.

Recent findings A number of new tools are on the horizon with the potential to overcome the problems of existing tests. These tools include new nucleic acid amplification platforms, real-time computer-assisted microscopy, next-generation sequencing and high-throughput mass spectrometry. All of these tests still face significant barriers before they can enter general clinical practice including cost, reliability and physician acceptance.

Summary Although new platforms are exciting and do offer the promise of finally moving beyond our current very limited scope of microbiological tests, empiric therapy based on knowledge of local epidemiological data is likely to remain the standard of care until the hurdles of proven accuracy, physician acceptance and cost-effectiveness are successfully negotiated.

aRoyal Melbourne Hospital, Victoria

bUniversity of Western Australia, Perth, Australia

cNorthwestern University, Chicago, Illinois, USA

Correspondence to Grant W. Waterer, MBBS, PhD, Professor of Medicine, University of Western Australia, Perth, Australia. E-mail:

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