The purpose of this review is to summarize the current knowledge regarding the diagnosis and treatment of indigenous new world hantavirus infections.
Recent studies have defined the incubation period of new world hantavirus infections, provided additional evidence for person-to-person transmission of Andes virus, described a rapid method for the presumptive diagnosis of infection in the cardiopulmonary phase through a review of the peripheral smear, and suggested that intravenous ribavirin is probably not effective for the treatment of new world hantavirus infections when started in the cardiopulmonary phase.
Presumptive diagnosis may be made by a review of the peripheral blood smear after the onset of the cardiopulmonary phase. Critical care management includes the avoidance of fluid overload, pressors to maintain cardiac output, and the use of extracorporeal membrane oxygenation in the most severe cases, but treatment with intravenous ribavirin is probably not effective.
aDepartments of Internal Medicine, USA
cPathology, University of New Mexico, Albuquerque, New Mexico, USA
dDepartments of Pediatrics, Chile
eAdult Intensive Care, Clinica Alemana School of Medicine, Universidad del Desarrollo, Santiago, Chile
Correspondence to Gregory J. Mertz, MD, Department of Internal Medicine, MSC10 5550, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA Tel: +1 505 272 5666; e-mail: email@example.com