Sexually transmitted diseases and urinary tract infectionsBacterial vaginosis and miscarriageHay, Phillip E Author Information Department of Genitourinary Medicine, St George's Hospital Medical School, London, UK Correspondence to Dr Phillip Hay, Senior Lecturer in Genitourinary Medicine, St George's Hospital Medical School, Cranmer Terrace, London, SW17 0QT, UK E-mail: [email protected] Abbreviation IVF: in-vitro fertilization Current Opinion in Infectious Diseases: February 2004 - Volume 17 - Issue 1 - p 41-44 Buy Abstract Purpose of review This review aims to summarize current knowledge about the relationship between bacterial vaginosis and miscarriage. Recent findings Studies investigating the relationship between bacterial vaginosis and infertility, implantation and early pregnancy loss have produced conflicting results. One study demonstrated a beneficial effect of colonization with hydrogen peroxide producing lactobacilli. A community based study found no association between bacterial vaginosis and first trimester loss, but a positive association with early second trimester loss. In a randomized controlled trial, treatment of bacterial vaginosis with oral clindamycin was associated with a fivefold reduction in the incidence of late miscarriage. Summary The relationship between bacterial vaginosis and infertility and first trimester loss needs further elucidation. Measures to support a healthy lactobacillus flora such as probiotic therapy warrant study. The randomized controlled trials of clindamycin treatment need to be replicated in different settings. © 2004 Lippincott Williams & Wilkins, Inc.