Review ArticleUrinary tract infection: new perspectives on a common diseaseCraig, Jonathan C.Author Information Department of Public Health and Community Medicine, University of Sydney; Centre for Kidney Research, and the Cochrane Renal Review Group, The Children's Hospital at Westmead, Westmead, New South Wales, Australia Correspondence to Jonathan C. Craig MBChB DCH MM (Clin Epi) PhD FRACP, Centre for Kidney Research, The Children's Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW, Australia. Tel: +61 2 9845 3431; fax: +61 2 9845 3432; e-mail: [email protected] Current Opinion in Infectious Diseases: June 2001 - Volume 14 - Issue 3 - p 309-313 Buy Abstract Urinary tract infection is an important cause of morbidity in children, and affects up to 10% of the childhood population. Recent information suggests that the long-term outcome for children with urinary tract infection is much better than previously believed, with causal links to end-stage renal disease and hypertension not demonstrated despite 20-year cohort studies. Improvements in the use of dipstick and clinical features as diagnostic tools have occurred, but culture is still needed if the diagnosis of urinary tract infection is to be definitively established. Interventions to prevent recurrent urinary tract infection, particularly low-dose, long-term antimicrobial agents may not be effective and placebo-controlled trials are now required. © 2001 Lippincott Williams & Wilkins, Inc.