Review ArticleEnteropathogenic and enterohaemorrhagic Escherichia coli and diarrhoeaRoe, Andrew J.; Gally, David L. Author Information Zoonotic and Animal Pathogens Research Laboratory, Medical Microbiology, University of Edinburgh, Edinburgh, UK Correspondence to David L. Gally, Zoonotic and Animal Pathogens Research Laboratory, Medical Microbiology, Teviot Place, University of Edinburgh, Edinburgh EH8 9AG, UK. Tel: +44 0131 651 1342; fax: +44 0131 650 6531; e-mail: [email protected] Abbreviations A/E: attaching and effacing BFP: bundle-forming pili EHEC: enterohaemorrhagic Escherichia coli EPEC: enteropathogenic Escherichia coli GFP: green fluorescent protein HUS: haemolytic uraemic syndrome LEE: locus of enterocyte effacement PCR: polymerase chain reaction Per: plasmid encoded regulator SLT: shiga-like toxin VTEC: verotoxigenic e. coli Current Opinion in Infectious Diseases 13(5):p 511-517, October 2000. Buy Abstract Enteropathogenic and enterohaemorrhagic Escherichia coli are important causes of bacterial gastroenteritis with the potential for progression to more serious syndromes, especially in the case of enterohaemorrhagic E. coli. Consequently, recent developments in molecular epidemiology and treatment regimens have focused on enterohaemorrhagic E. coli, while the similar initial pathogenic mechanisms of both enterohaemorrhagic and enteropathogenic E. coli continue to be investigated in detail. The carriage of most E. coli virulence determinants on pathogenicity islands, plasmids or phages allows the rapid evolution of these pathotypes, which need to be monitored closely. © 2000 Lippincott Williams & Wilkins, Inc.