Review ArticleDengue haemorrhagic fever: questions of pathogenesisCardosa, Mary Jane Author Information Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia Correspondence to Mary Jane Cardosa, Institute of Health and Community Medicine, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia. Tel: +60 82 671 730; fax: +60 82 671 903; e-mail: [email protected] Abbreviations ADE: antibody-dependent enhancement CNS: central nervous system CSF: cerebrospinal fluid DHF: dengue haemorrhagic fever DSS: dengue shock syndrome JEV: Japanese encephalitis virus RT-PCR: reverse transcriptase-polymerase chain reaction WHO: World Health Organization Current Opinion in Infectious Diseases 13(5):p 471-475, October 2000. Buy Abstract The year under review has seen a remarkable proliferation of papers on dengue. Four prospective studies have been carried out across the dengue belt, many groups have been pushing at the question of pathogenesis of dengue haemorrhagic fever, and a breakthrough has been achieved in the development of a mouse model for human dengue haemorrhagic fever. © 2000 Lippincott Williams & Wilkins, Inc.