Antimicrobial resistance in both bacteria and fungi continues to cause concern, including the prospect of amphotericin resistance in common yeasts. A changing pattern of fungal infections has been reported from several centres but the early diagnosis of fungal infection is still problematic. New studies of antibacterials show that monotherapy with meropenem is efficacious in both adults and children, but a significant increase in efficacy is unlikely to be seen with any new antibacterial agent under development. Adjunctive therapy with colony stimulating factors gives improved results in fungal infections which are normally very refractory to treatment.
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