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Davies Jane; Bush, Andrew
Current Opinion in Infectious Diseases: August 1997
Infections of the immunocompromised host: PDF Only
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Three models which attempt to account for the interaction between Pseudomonas aeruginosa and cystic fibrosis respiratory epithelium have been developed. These are: (1) malfunction of the defensin system as a result of altered chloride content of the airway fluid; (2) loss of cystic fibrosis transmembrane conductance regulator, which acts as a receptor for Pseudomonas aeruginosa, leading to the failure of internalization of the bacteria; (3) upregulation of asialo GM1 receptors and increased Pseudomonas aeruginosa binding. Other important advances include new uses of antibiotics for resistant strains and the vexed question of infection control strategies.

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