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DiNubile Mark J. MD
Current Opinion in Infectious Diseases: October 1991
Generalized infections: PDF Only
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Recent developments have furthered our understanding of endocardi- tis associated with intravenous drug use. Pathogenic differences between right- and left-sided endocarditis have clinically significant implications. Vancomycin may be suboptimal treatment for endocarditis due to methicillin-sensitive Staphylococcus aureus. Except for advanced disease, infection with the human immunodeficiency virus does not alter the course of endocarditis in drug users with both infections. Patients with left-sided endocarditis caused by Pseudornonas aeruginosa frequently suffer major complications; valve replacement is often required, but the optimal timing of surgical intervention is still debated.

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