Visualization of HIV-1 reservoir: an imaging perspective : Current Opinion in HIV and AIDS

Secondary Logo

Journal Logo

HIV RESERVOIR: Edited by Matthieu Perreau and Constantinos Petrovas

Visualization of HIV-1 reservoir: an imaging perspective

Chapon, Catherinea; Moysi, Eirinib; Naninck, Thibauta; Mayet, Celinea; Petrovas, Constantinosc

Author Information
Current Opinion in HIV and AIDS 16(4):p 232-239, July 2021. | DOI: 10.1097/COH.0000000000000691


Purpose of review 

The persistence of HIV-1-infected cells, despite the introduction of the combinatorial antiretroviral therapy, is a major obstacle to HIV-1 eradication. Understanding the nature of HIV reservoir will lead to novel therapeutic approaches for the functional cure or eradication of the virus. In this review, we will update the recent development in imaging applications toward HIV-1/simian immunodeficiency virus (SIV) viral reservoirs research and highlight some of their limitations.

Recent findings 

CD4 T cells are the primary target of HIV-1/SIV and the predominant site for productive and latent reservoirs. This viral reservoir preferentially resides in lymphoid compartments that are difficult to access, which renders sampling and measurements problematical and a hurdle for understanding HIV-1 pathogenicity. Novel noninvasive technologies are needed to circumvent this and urgently help to find a cure for HIV-1. Recent technological advancements have had a significant impact on the development of imaging methodologies allowing the visualization of relevant biomarkers with high resolution and analytical capacity. Such methodologies have provided insights into our understanding of cellular and molecular interactions in health and disease.


Imaging of the HIV-1 reservoir can provide significant insights for the nature (cell types), spatial distribution, and the role of the tissue microenvironment for its in vivo dynamics and potentially lead to novel targets for the virus elimination.

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

You can read the full text of this article if you:

Access through Ovid