HIV-ASSOCIATED CO-MORBIDITIES: Edited by Morris Schambelan and Todd T. BrownCurrent co-morbidities burden in patients living with HIV in low- and middle-income countriesPonatshego, Ponego Lloyda; Youssouf, Nabila Farahb; Mosepele, Mosepelec,dAuthor Information aResearch Physician and Principal Investigator, Botswana Harvard HIV/AIDS Partnership bProgram Manager, Botswana Harvard HIV/AIDS Partnership cAssociate Professor, Infectious Diseases; Head of Department, Internal Medicine, University of Botswana dPrincipal Investigator, Botswana Harvard HIV/AIDS Partnership Correspondence to Ponego Lloyd Ponatshego, MD, Research Physician, Botswana Harvard HIV/AIDS Partnership, Private Bag BO320, Gaborone, Botswana. E-mail: [email protected] Current Opinion in HIV and AIDS: May 2021 - Volume 16 - Issue 3 - p 163-167 doi: 10.1097/COH.0000000000000676 Buy Metrics Abstract Purpose of review The present review aims to decipher common co-morbidities faced by people living with HIV in low- to middle-income countries, and in particular the sub-Saharan region, which hosts the majority of the HIV burden worldwide. Recent findings Well-controlled chronic HIV disease is strongly associated with an increased risk of developing cardiovascular disease. This is partly due to the natural aging process, however recent studies show that using antiretroviral therapy as well as the HIV disease itself may be predisposing factors to the development of cardiovascular diseases, creating a new burden for healthcare facilities in the region. Furthermore, newly completed studies assessing inflammation marker albuminuria and age-related syndrome frailty have been found in a higher prevalence than in non-HIV infected people, with increased morbidity and mortality. Summary As antiretroviral medication continues to be well supplied in the region and well tolerated by patients living with HIV, this group is now reckoning with cardiovascular ailments faced by all ageing population therefore there is a need for cardiovascular care systems to be better integrated within the existing, well-performing HIV care systems to address this burden. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.