LONG ACTING ART FOR TREATMENT AND PREVENTION: Edited by Martin MarkowitzLong-acting injectable cabotegravir for the prevention of HIV infectionClement, Meredith E.a; Kofron, Ryanb; Landovitz, Raphael J.bAuthor Information aLouisiana State University Health Sciences Center, New Orleans, LA bUCLA Center for Clinical AIDS Research and Education, Los Angeles, California, USA Correspondence to Raphael J. Landovitz, UCLA Center for Clinical AIDS Research and Education, 11075 Santa Monica Blvd, Suite 100, Los Angeles, CA 90025, USA. E-mail: [email protected] Current Opinion in HIV and AIDS: January 2020 - Volume 15 - Issue 1 - p 19-26 doi: 10.1097/COH.0000000000000597 Buy Metrics Abstract Purpose of review This review highlights the development of long-acting injectable cabotegravir (CAB LA) for HIV preexposure prophylaxis (PrEP), with a focus on phase 2 studies and later development. Recent findings Early studies of CAB LA for HIV prevention offered promising pharmacokinetic data and paved the way for phase 2 studies, which have now been completed. On the basis of phase 2 data, dosing of CAB LA at 8-week intervals consistently delivers target trough concentrations in both men and women. Recent studies have shown no required dose adjustments for hepatic or renal disease and minimal drug--drug interactions. Additionally, injectable PrEP is desired by potential PrEP candidates. Still, gaps in knowledge remain with respect to implementation and delivery, the clinical significance of the pharmacologic tail, and dosing in key populations. Phase 3 trials are underway that are anticipated to inform some of these questions and provide efficacy and safety data to support regulatory submissions for CAB LA as a potential PrEP agent. Summary Recent studies have defined an appropriate CAB LA dosing interval and offered insight into its safety profile. Phase 3 studies will provide much-anticipated efficacy data. If efficacious, CAB LA may provide a desirable PrEP option for those who face challenges to daily pill adherence. A more complete understanding of how to best integrate LA PrEP into service delivery models will be critical for success. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.