CONCENTRATED EPIDEMICS: Edited by Sheena McCormack, Rachel Baggaley and Kevin M. DeCockComprehensive HIV risk reduction interventions for 2020 and beyond product choices and effective service-delivery platforms for individual needs and population-level impactVelloza, Jennifera,b; Delany-Moretlwe, Sineadc; Baeten, Jared M.a,b,d Author Information aDepartment of Global Health, University of Washington bDepartment of Epidemiology, University of Washington, Seattle, USA cFaculty of Health Sciences, Wits Reproductive Health & HIV Institute (WRHI), University of the Witwatersrand, Johannesburg, South Africa dDepartment of Medicine, University of Washington, Seattle, USA Correspondence to Jared M. Baeten, MD, PhD, International Clinical Research Center, University of Washington, Box 359927, 325 Ninth Avenue, Seattle, WA 98104, USA. Tel: +1 206 520 3808; e-mail: [email protected] Current Opinion in HIV and AIDS: September 2019 - Volume 14 - Issue 5 - p 423-432 doi: 10.1097/COH.0000000000000567 Buy Metrics Abstract Purpose of review This review summarizes key HIV prevention strategies in the 2020 toolkit and discusses opportunities to maximize the public health impact of these prevention interventions at a population level. Recent findings HIV prevention has relied on counseling, HIV testing, and condom distribution for the past three decades. Recent exciting work has provided evidence on effective HIV prevention interventions, including antiretroviral therapy for HIV prevention, expanding preexposure prophylaxis modalities, and voluntary medical male circumcision which all reduce individual-level HIV risk. Efficient service-delivery approaches are necessary to deliver these products at scale while addressing population-specific needs. These approaches include: making it easier to get individuals HIV tested and linked to prevention services; de-medicalization to increase access to prevention products; creating welcoming clinic service-delivery environments; and integrating HIV prevention products into existing clinical platforms to support ongoing care engagement. Summary The 2020 HIV prevention toolkit includes powerful HIV prevention options, and product choice will be increasingly imperative. Meeting ambitious global HIV reduction targets in the next decade will require improved service-delivery platforms to get prevention choices to persons at risk while layering prevention coverage to achieve population-level impact. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.