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HIV-1 phylogenetics and vaccines

Rolland, Morganea,b

Current Opinion in HIV and AIDS: May 2019 - Volume 14 - Issue 3 - p 227–232
doi: 10.1097/COH.0000000000000545
PHYLOGENETICS IN HIV TRANSMISSION: Edited by Morgane Rolland and Josh Herbeck
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Purpose of review Although HIV-1 diversity is a critical barrier to HIV-1 vaccine development, implementing vaccine strategies that directly address HIV-1 genetic specificities has been challenging. Here, we discuss the intersection between HIV-1 phylogenetics and vaccine development.

Recent findings We describe the vaccine regimens that are currently tested in two vaccine efficacy trials and recent research highlighting HIV-1 genetic features that were associated with the development of broadly neutralizing antibodies.

Summary Compared with how widely HIV-1 diversity is recognized as a critical issue for vaccine research, relatively few genetically informed vaccine solutions have been compared, in part because the lack of correlates of protection against HIV-1 limits the ability to develop and test multiple vaccine candidates in a fully rational manner. Yet, recent findings have provided a better understanding of the viral features associated with the development of broad and potent neutralizing antibodies, offering new avenues for engineering vaccine candidates. Future research should also plan to address potential consequences associated with the rollout of an efficacious vaccine, including the possibility of vaccine resistance spreading in the population.

aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD

bHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA

Correspondence to Morgane Rolland, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, and Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA. Tel: +1 301 319 9329; fax: +1 301 319 9329; e-mail: mrolland@hivresearch.org

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