CARDIOVASCULAR DISEASE IN HIV INFECTED PERSONS: Edited by Franck Boccara and Cameron J. HollowayCurrent assessment of heart rate variability and QTc interval length in HIV/AIDSMcIntosh, Roger C.a; Lobo, Judith D.a; Hurwitz, Barry E.a,b,c Author Information aDepartment of Health Psychology, University of Miami, Coral Gables, Florida bBehavioral Medicine Research Center cDivision of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, Florida, USA Correspondence to Roger C. McIntosh, PhD, Department of Health Psychology, University of Miami, Miami, FL 33124, USA. Tel: +1 305 243 1467; fax: +1 305 243 2047; e-mail: [email protected] Current Opinion in HIV and AIDS: November 2017 - Volume 12 - Issue 6 - p 528-533 doi: 10.1097/COH.0000000000000408 Buy Metrics Abstract Purpose of review The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. Recent findings Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood. Recent literature also suggests the trend of lower heart rate variability in HIV is indicative of cardiorespiratory and inflammatory-immune dysfunction. Summary These emergent studies support the clinical relevance of the ECG across the age and HIV disease spectrum. Furthermore, the reported findings have implications for the management of cardiovascular and chronic inflammatory disease comorbidity in persons living with HIV. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.