HIV AND NOVEL STRATEGIES FOR INDUCTION OF BROAD NEUTRALIZING ANTIBODIES FOLLOWING VACCINATION: Edited by Ralf WagnerRole of nonneutralizing antibodies in vaccines and/or HIV infected individualsMayr, Luziaa; Su, Binb; Moog, ChristianeaAuthor Information aINSERM U1109, FMTS, University of Strasbourg, Strasbourg, France bBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, China Correspondence to Christiane Moog, PhD, INSERM U1109, FMTS, University of Strasbourg, 3 rue Koeberlé, Strasbourg 67000, France. E-mail: firstname.lastname@example.org Current Opinion in HIV and AIDS: May 2017 - Volume 12 - Issue 3 - p 209-215 doi: 10.1097/COH.0000000000000357 Buy Metrics Abstract Purpose of review Increased body of evidence gathered over time indicate that antibodies are capable of many inhibitory mechanisms, virus neutralization being just one of them. Nonneutralizing antibodyactivities interfering with HIV replication can also lead to a decrease in viral load and even in-vivo protection. Recent findings It was previously believed that neutralizing antibodies can achieve sterilizing protection mainly by using their neutralization capacities against the infecting virus directly at the portal of virus entry. Recent findings show that protection can be obtained by neutralizing antibodiesat distal sites of virus challenge. In this case, foci of virus infection that escaped from initial inhibition of virus are eliminated presumably by additional nonneutralizing antibody activities. These data inexorably strengthen the diverse functions of antibodies and broaden their role as antiviral mediator. Summary The review summarizes the current knowledge and the difficulties to encompass the numerous functions of antibodies. A complete understanding of the various facets of antibody functions is required to efficiently induce them via next-generation vaccine design. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.