HIV AND NOVEL STRATEGIES FOR INDUCTION OF BROAD NEUTRALIZING ANTIBODIES FOLLOWING VACCINATION: Edited by Ralf WagnerLessons learned from humoral responses of HIV patientsMcCoy, Laura E.a; McKnight, ÁinebAuthor Information aDivision of Infection & Immunity, University College London bCenter for Immunobiology, Barts and The London School of Medicine and Dentistry, Blizard Institute, London, UK Correspondence to Laura E. McCoy, Division of Infection & Immunity, University College London, Cruciform Building, London WC1E 6BT, UK. Tel: +44 0 2031082137; e-mail: [email protected] Current Opinion in HIV and AIDS: May 2017 - Volume 12 - Issue 3 - p 195-202 doi: 10.1097/COH.0000000000000361 Buy Metrics Abstract Purpose of review Since 2009 many broadly neutralizing antibodies against HIV have been identified, yet there is still no vaccine capable of inducing such antibodies in humans. This review considers the early observations of HIV sera neutralization in light of more recent studies and highlights areas for future research. Recent findings Large clinical cohort studies using standardized neutralization assays and pseudoviruses derived from primary isolates have shown that 10–30% of HIV infections result in some level of serum neutralization breadth. However, less than 10% of individuals develop a greater breadth of neutralization and are termed elite neutralizers. Summary During HIV infection, many individuals develop strain-specific neutralization against their viral quasispecies, and similar immunogen-matched activity can now be induced in animal models. However, only in a minority of infections do broadly neutralizing antibodies develop. Therefore, understanding how the viral diversity, host immune environment, and antibody repertoires intersect to support the generation of neutralization breadth in elite neutralizers could provide guidelines as to how to improve immunization responses. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.