SURVIVAL IN THE MODERN ART ERA: Edited by Margaret May and Dominique CostagliolaTrends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe comparisons with general populationWandeler, Gilles; Johnson, Leigh F.; Egger, MatthiasAuthor Information aDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland bInstitute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland cDepartment of Infectious Diseases, University of Dakar, Senegal dCentre for Infectious Disease Epidemiology and Research (CIDER), University of Cape Town, South Africa Correspondence to Prof. Dr Matthias Egger, Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, CH-3012 Bern, Switzerland. E-mail: [email protected] Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-hivandaids.com). Current Opinion in HIV and AIDS: September 2016 - Volume 11 - Issue 5 - p 492-500 doi: 10.1097/COH.0000000000000298 Buy SDC Metrics Abstract Purpose of review Improved virological and immunological outcomes and reduced toxicity of antiretroviral combination therapy (ART) raise the hope that life expectancy of HIV-positive persons on ART will approach that of the general population. We systematically review the literature and summarize published estimates of life expectancy of HIV-positive populations on ART. We compare their life expectancy with the life expectancy of the general or, in sub-Saharan Africa, HIV-negative populations, by time period and gender. Recent findings Ten relevant studies were published from 2006 to 2015. Three studies were from Canada, two from European countries, three from sub-Saharan Africa and two were multicountry studies. Life expectancy increased over time in all studies and regions. Expressed as the percentage of life expectancy in the HIV-negative or general population, estimated life expectancy at age 20 years in HIV-positive people on ART ranged from 60.3% (95% CI 58.0–62.6%) in Rwanda (2008–2011) to 89.1% (95% CI 84.7–93.6%) in Canada (2008–2012). The percentage of life expectancy in the HIV-negative or general population achieved was higher in HIV-positive women than in HIV-positive men in all countries, except for Canada wherein the opposite was the case. Summary Life expectancy in HIV-positive people on ART has improved worldwide in recent years, but important gaps remain compared with the general and HIV-negative population, and between regions and genders. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.