STRATEGIES FOR TARGETING RESIDUAL HIV INFECTION: Edited by Matthieu Perreau and Nicolas ChomontStrategies to target non-T-cell HIV reservoirsSacha, Jonah B.; Ndhlovu, Lishomwa C.Author Information aVaccine and Gene Therapy Institute bOregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon cDepartment of Tropical Medicine dHawaii Center for AIDS, University of Hawaii, Honolulu, Hawaii, USA Correspondence to Lishomwa C. Ndhlovu, MD, PhD, Hawaii Center for AIDS, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA. Tel: +1 808 692 1604; fax: +1 808 692 1984; e-mail: email@example.com Current Opinion in HIV and AIDS: July 2016 - Volume 11 - Issue 4 - p 376-382 doi: 10.1097/COH.0000000000000283 Buy Metrics Abstract Purpose of review A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4+ T cells, particularly in anatomical areas of low drug penetrability. Recent findings HIV eradication strategies being positioned for targeting HIV for extinction in the CD4+ T-cell compartment may also show promise in non-CD4+ T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4+ T-cell populations are being developed. Summary Although reservoir validity in these non-CD4+ T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.