This article describes the mechanisms and consequences of both microbial translocation and microbial dysbiosis in HIV infection.
Microbes in HIV are likely playing a large role in contributing to HIV pathogenesis, morbidities and mortality. Two major disruptions to microbial systems in HIV infection include microbial translocation and microbiome dysbiosis. Microbial translocation occurs when the bacteria (or bacterial products) that should be in the lumen of the intestine translocate across the tight epithelial barrier into systemic circulation, where they contribute to inflammation and pathogenesis. This is associated with poorer health outcomes in HIV-infected individuals. In addition, microbial populations in the gastrointestinal tract are also altered after HIV infection, resulting in microbiome dysbiosis, which further exacerbates microbial translocation, epithelial barrier disruption, inflammation and mucosal immune functioning.
Altered microbial regulation in HIV infection can lead to poor health outcomes, and understanding the mechanisms underlying microbial dysbiosis and translocation may result in novel pathways for therapeutic interventions.
aDepartment of Pharmaceutics, University of Washington
bWashington National Primate Research Center, Seattle, Washington, USA
cCentre for the AIDS Programme of Research (CAPRISA), Durban, South Africa
dDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba
eNational Laboratory for HIV Immunology, JC Wilt Infectious Disease Research Center, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
fDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska, Sweden
Correspondence to Nichole R. Klatt, Department of Pharmaceutics, University of Washington, Seattle, Washington, USA. Tel: +1 206 221 0254; e-mail: klattnr@uw.edu
