IMMUNE ACTIVATION: Edited by Irini Sereti and Marcus AltfeldImmune activation and cardiovascular disease in chronic HIV infectionLongenecker, Chris T.; Sullivan, Claire; Baker, Jason V.Author Information aUniversity Hospitals Harrington Heart and Vascular Institute bCase Western Reserve University School of Medicine, Cleveland, Ohio cHennepin County Medical Center dUniversity of Minnesota; Minneapolis, Minnesota, USA Correspondence to Jason V. Baker, Division of Infectious Diseases, Hennepin County Medical Center, University of Minnesota, 701 Park Avenue, MC G5, Minneapolis, MN 55417, USA. Tel: +1 612 873 2705; fax: +1 612 904 4299; e-mail: [email protected] Current Opinion in HIV and AIDS: March 2016 - Volume 11 - Issue 2 - p 216-225 doi: 10.1097/COH.0000000000000227 Buy Metrics Abstract Purpose of review This article describes the potential contribution of immune activation in the pathogenesis of HIV-associated cardiovascular disease (CVD) – a leading cause of morbidity and mortality among HIV-positive persons with access to antiretroviral therapy (ART). Recent findings We review recent literature that suggests abnormalities in both adaptive and innate immunity contributes to CVD risk among persons with HIV infection. In particular, potentially atherogenic T-cell mechanisms include persistent high-level T-cell activation (and associated proinflammatory mechanisms), as well as the presence of copathogens (e.g., cytomegalovirus) providing an ongoing stimulus for cytotoxic T-cell responses. More recent data have then emphasized the potential impact of monocyte-/macrophage-mediated inflammation and injury within atherosclerotic lesions. The abnormality driving innate immune activation many not fully reverse with antiretroviral therapy, highlighting the need for interventions that target inflammation as a CVD prevention strategy. Summary Premature CVD among persons with HIV infection is due, in part, to persistent abnormalities in immune activation and systemic inflammation despite viral suppression. Prevention strategies for persons with HIV infection include those that target traditional CVD risk factors, as well as newer candidate treatments with potential immunomodulatory benefits. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.