Institutional members access full text with Ovid®

Share this article on:

Nonreplicating vectors in HIV vaccines

Johnson, Jennifer A.; Barouch, Dan H.; Baden, Lindsay R.

Current Opinion in HIV and AIDS: September 2013 - Volume 8 - Issue 5 - p 412–420
doi: 10.1097/COH.0b013e328363d3b7
CHANGING ENVIRONMENT IN HIV VACCINE: Edited by Nelson L. Michael and Glenda Gray

Purpose of review We review the broad spectrum of nonreplicating viral vectors which have been studied extensively, from preclinical studies through clinical efficacy trials, and include some of our most promising HIV vaccine candidates.

Recent findings The success of the RV144 trial, with a canarypox virus-based regimen, contrasts with the failures of the adenovirus-5 (Ad5)-based regimens in the Step study, the Phambili study [HIV Vaccine Trials Network (HVTN) 503], and the HVTN 505 study which was recently modified to halt vaccinations because of clinical futility.

Summary The safety profile, immunogenicity, and variety of available candidates make the nonreplicating viral vectors attractive in HIV vaccine development. Building from the success of the RV144 study, further studies of Orthopoxvirus-based vaccines, including vaccinia-based vaccines, are ongoing and planned for the future. Despite the failures of the Ad5-based vaccines in clinical efficacy trials, other adenovirus serotypes remain promising candidates, especially in prime–boost combination with other products, and with the potential use of mosaic inserts. Other nonreplicating viral vectors such as the rhabdoviruses, alphaviruses, and the nonhuman adenoviruses, provide additional avenues for exploration.

aDivision of Infectious Diseases, Brigham and Women's Hospital

bCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center

cHarvard Medical School, Boston, Massachusetts, USA

Correspondence to Jennifer A. Johnson, MD, Division of Infectious Diseases, PBB-A4, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Tel: +1 617 732 6660; fax: +1 617 732 6829; e-mail:

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.