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New paradigms for functional HIV-specific nonneutralizing antibodies

Forthal, Don; Hope, Thomas J.; Alter, Galit

Current Opinion in HIV and AIDS: September 2013 - Volume 8 - Issue 5 - p 393–401
doi: 10.1097/COH.0b013e328363d486
CHANGING ENVIRONMENT IN HIV VACCINE: Edited by Nelson L. Michael and Glenda Gray

Purpose of review Although a large number of novel broadly neutralizing antibodies has been recently described, the induction of such antibodies via vaccination has proven difficult. By contrast, nonneutralizing antibodies arise early during infection and have been repeatedly associated with both protection from infection and disease progression.

Recent findings We are beginning to gain new insights into the broader landscape of antiviral mechanisms that nonneutralizing antibodies may harness to fight HIV, providing an unprecedented breadth of approaches by which HIV can be blocked and contained.

Summary In this review, we summarize the characteristics of nonneutralizing antibodies, their role in HIV infection, and new paradigm-shifting functions that may be exploited by next-generation vaccine approaches aimed at blocking HIV infection.

aUniversity of California, Irvine, California

bDepartment of Cell & Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

cRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA

Correspondence to Galit Alter, Ragon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA 02139, USA. Tel: +1 857 268 7003; e-mail:

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.