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Preclinical primate studies of HIV-1-envelope-based vaccines: towards human clinical trials

Heeney, Jonathan L

Current Opinion in HIV and AIDS: July 2006 - Volume 1 - Issue 4 - p 336–343
doi: 10.1097/01.COH.0000232350.61650.f0
HIV vaccines: Clinical science
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Purpose of review There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine candidates to clinical trials.

Recent findings There is a strong desire to have one clear ‘immune correlate’ of protection from HIV/AIDS to guide clinical vaccine development. This is unlikely to emerge, as immunity to HIV-1 is interdependent and very complex (i.e. quality versus quantity). Thus the problem can better be focused on the definition of the specific vaccine question being asked and the correct design of the preclinical study. Only now are head-to-head comparison studies being designed to directly compare immune responses in humans with those exact same vaccine candidates in rhesus monkeys.

Summary Whereas T-cell-based vaccine candidates are being developed and advanced, the needs from the macaque model are for comparative immunogenicity and ‘predictive outcomes’ to refine and facilitate clinical trial design. With respect to neutralizing antibody (B-cell) vaccine strategies, the needs are currently at earlier discovery and proof-of-concept stages requiring HIV-1-envelope-based SHIV-challenges.

Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands

Correspondence to Jonathan L. Heeney, DVM, DVSc, PhD, Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, PO Box 3306, 2280 GH Rijswijk, The Netherlands Tel: +31 15 284 2661; fax: +31 15 284 2601; e-mail: heeney@bprc.nl

© 2006 Lippincott Williams & Wilkins, Inc.