Meningeal Lymphatic vasculature in health and disease : Current Opinion in Hematology

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VASCULAR BIOLOGY: Edited by M. Luisa Iruela-Arispe

Meningeal Lymphatic vasculature in health and disease

Busch, Nishaa,∗; O’Reilly, Liama,∗; Louveau, Antoineb,c,d

Author Information

aNeuroscience Undergraduate Program, Case Western Reserve University

bDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic

cDepartment of Molecular Medicine, Cleveland Clinic College of Medicine, Case Western Reserve University

dDepartment of Neuroscience, School of Biomedical Sciences, Kent State University, Cleveland Ohio, USA

Correspondence to Antoine Louveau, PhD, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA. Tel: +216 445 9362; e-mail: [email protected]

Current Opinion in Hematology 29(3):p 151-155, May 2022. | DOI: 10.1097/MOH.0000000000000711

Abstract

Purpose of review 

The recent (re)discovery of the meningeal lymphatic has brought a new player in brain neurophysiology. This review highlights the state of the current research on the meningeal lymphatic vasculature, from its specific physiology to its increasing implication in normal and pathological brain function.

Recent findings 

Growing evidence are emerging about the uniqueness of the meningeal lymphatic vasculature and its implication in multiple neurological and neurotraumatic disorders.

Summary 

These studies are highlighting a new and unexpected role for the lymphatic vasculature in brain function and a potential new therapeutic target for neurological disorders.

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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