VASCULAR BIOLOGY: Edited by M. Luisa Iruela-ArispeMeningeal Lymphatic vasculature in health and diseaseBusch, Nishaa,∗; O’Reilly, Liama,∗; Louveau, Antoineb,c,d Author Information aNeuroscience Undergraduate Program, Case Western Reserve University bDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic cDepartment of Molecular Medicine, Cleveland Clinic College of Medicine, Case Western Reserve University dDepartment of Neuroscience, School of Biomedical Sciences, Kent State University, Cleveland Ohio, USA Correspondence to Antoine Louveau, PhD, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA. Tel: +216 445 9362; e-mail: [email protected] Current Opinion in Hematology 29(3):p 151-155, May 2022. | DOI: 10.1097/MOH.0000000000000711 Buy Metrics Abstract Purpose of review The recent (re)discovery of the meningeal lymphatic has brought a new player in brain neurophysiology. This review highlights the state of the current research on the meningeal lymphatic vasculature, from its specific physiology to its increasing implication in normal and pathological brain function. Recent findings Growing evidence are emerging about the uniqueness of the meningeal lymphatic vasculature and its implication in multiple neurological and neurotraumatic disorders. Summary These studies are highlighting a new and unexpected role for the lymphatic vasculature in brain function and a potential new therapeutic target for neurological disorders. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.