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Krüppel-like factors in endothelial cell biology

Chang, Eugene; Nayak, Lalitha; Jain, Mukesh K.

Current Opinion in Hematology: May 2017 - Volume 24 - Issue 3 - p 224–229
doi: 10.1097/MOH.0000000000000337
VASCULAR BIOLOGY: Edited by Edward F. Plow

Purpose of review Krüppel-like factors (KLFs) are a family of transcription factors that regulate integral functions of endothelial cells including inflammation, proliferation, growth, apoptosis, cell differentiation and plasticity, and migration. This review will focus on the role of KLFs in physiological activity and their loss in vascular pathology.

Recent findings New studies have pointed at the role of microRNAs as repressors of KLFs in atherosclerotic areas providing another level of signaling regulation of KLFs.

Summary KLFs are important regulators of almost all facets of endothelial biology, making them a promising therapeutic target in the treatment of endothelial dysfunction and cardiovascular disease. Further research is needed to fully characterize their functions.

Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Correspondence to Mukesh K. Jain, MD, Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, 2103 Cornell Rd, Cleveland, OH 44106, USA. Tel: +1 216 368 3607; e-mail: Mukesh.Jain2@case.edu

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