ERYTHROID SYSTEM AND ITS DISEASES: Edited by Narla Mohandas and Sandrina KinetSmall molecule therapeutics to treat the β-globinopathiesYu, Lei; Myers, Greggory; Engel, James D.Author Information Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA Correspondence to James D. Engel, Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Tel: +1 734 615 7248; e-mail: firstname.lastname@example.org Current Opinion in Hematology: May 2020 - Volume 27 - Issue 3 - p 129-140 doi: 10.1097/MOH.0000000000000579 Buy Metrics Abstract Purpose of review The current review focuses on recent insights into the development of small molecule therapeutics to treat the β-globinopathies. Recent findings Recent studies of fetal γ-globin gene regulation reveal multiple insights into how γ-globin gene reactivation may lead to novel treatment for β-globinopathies. Summary We summarize current information regarding the binding of transcription factors that appear to be impeded or augmented by different hereditary persistence of fetal hemoglobin (HPFH) mutations. As transcription factors have historically proven to be difficult to target for therapeutic purposes, we next address the contributions of protein complexes associated with these HPFH mutation-affected transcription factors with the aim of defining proteins that might provide additional targets for chemical molecules to inactivate the corepressors. Among the enzymes associated with the transcription factor complexes, a group of corepressors with currently available inhibitors were initially thought to be good candidates for potential therapeutic purposes. We discuss possibilities for pharmacological inhibition of these corepressor enzymes that might significantly reactivate fetal γ-globin gene expression. Finally, we summarize the current clinical trial data regarding the inhibition of select corepressor proteins for the treatment of sickle cell disease and β-thalassemia. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.