Purpose of review
This review highlights recent insights into the role of platelets
in acute inflammation
Recent findings Platelets
exhibit intravascular crawling behavior and can collect and bundle bacteria. In addition, platelets
are key in promoting intravascular thrombus formation in infection, a process termed ‘immunothrombosis’, which contributes to pathogen containment, but also potentially damages the host. Platelets
are at the nexus of leukocyte recruitment and activation, yet they are at the same time crucial in preventing inflammation
-associated hemorrhage and tissue damage. This multitasking requires specific receptors and pathways, depending on stimulus, organ and effector function.
New findings highlight the complex interplay of innate immunity
, coagulation and platelets
and infection, and unravel novel molecular pathways and effector functions. These offer new potential therapeutic approaches, but require further extensive research to distinguish treatable proinflammatory from host–protective pathways.