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Neutropenia in glycogen storage disease Ib

outcomes for patients treated with granulocyte colony-stimulating factor

Dale, David C.a; Bolyard, Audrey Annab; Marrero, Tracyb; Kelley, Merideth L.a; Makaryan, Vahagna; Tran, Emilyb; Leung, Jamieb; Boxer, Laurence A.c; Kishnani, Priya S.d; Austin, Stephanied; Wanner, Corbiniane; Ferrecchia, Iris A.e; Khalaf, Dinaf; Maze, Dawnf; Kurtzberg, Joanneg; Zeidler, Corneliah; Welte, Karli; Weinstein, David A.e

Current Opinion in Hematology: January 2019 - Volume 26 - Issue 1 - p 16–21
doi: 10.1097/MOH.0000000000000474
MYELOID BIOLOGY: Edited by David C. Dale

Purpose of review Glycogen storage disease Ib (GSD Ib) is characterized by hepatomegaly, hypoglycemia, neutropenia, enterocolitis and recurrent bacterial infections. It is attributable to mutations in G6PT1, the gene for the glucose-6-phosphate transporter responsible for transport of glucose into the endoplasmic reticulum. Neutropenia in GSD Ib is now frequently treated with granulocyte colony-stimulating factor (G-CSF). We formed a cooperative group to review outcomes of the long-term treatment of GSD Ib patients treated with G-CSF.

Recent findings The study enrolled 103 patients (48 men and 55 women), including 47 currently adult patients. All of these patients were treated with G-CSF, starting at a median age of 3.8 years (range 0.04–33.9 years) with a median dose of 3.0 mcg/kg/day (range 0.01–93.1 mcg/kg/day) for a median of 10.3 years (range 0.01–29.3 years). Neutrophils increased in response to G-CSF in all patients (median values before G-CSF 0.2 × 109/l, on G-CSF 1.20 x 109/l). Treatment increased spleen size (before G-CSF, 47%, on treatment on G-CSF 76%), and splenomegaly was the dose-limiting adverse effect of treatment (pain and early satiety). Clinical observations and records attest to reduce frequency of infectious events and the severity of inflammatory bowel symptoms, but fever and recurrent infections remain a significant problem. In the cohort of patients followed carefully through the Severe Chronic Neutropenia International Registry, four patients have developed myelodysplasia or acute myeloid leukemia and we are aware of four other cases, (altogether seven on G-CSF, one never treated with G-CSF). Liver transplantation in five patients did not correct neutropenia. Four patients had hematopoietic stem cell transplantation; two adults and two children were transplanted; one adult and one child survived.

Summary GSD Ib is a complex disorder of glucose metabolism causing severe chronic neutropenia. G-CSF is effective to raise blood neutrophil counts and reduce fevers and infections in most patients. In conjunction with other therapies (salicylates, mesalamine sulfasalazine and prednisone), G-CSF ameliorates inflammatory bowel symptoms, but doses must be limited because it increases spleen size associated with abdominal pain.

aDivision of GIM, Department of Medicine, University of Washington

bDepartment of Medicine, University of Washington, Severe Chronic Neutropenia International Registry, Seattle, Washington

cPediatric Hematology Oncology, University of Michigan, Ann Arbor, Michigan

dDivision of Medical Genetics, Duke University Medical Center, Durham, North Carolina

eDepartment of Pediatrics, Glycogen Storage Disease Program, Connecticut Children's Medical Center, Hartford, Connecticut, USA

fDepartment of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

gDepartment of Pediatrics/Pediatric Blood and Marrow Transplantation/Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA

hDepartment of Molecular Hematopoiesis, Medizinische Hochschule Hannover, Hannover

iDivision of Hematology/Oncology, Department of Molecular Hematopoiesis, University Children's Hospital of Tuebingen, Tuebingen, Germany

Correspondence to David C. Dale, MD, Division of GIM, Department of Medicine, University of Washington, Box 356422, 1959 NE Pacific St., Rm AA522, Seattle, WA 98195, USA. Tel: +1 206-543-7218; fax: +1 206-685-4458; e-mail: dcdale@uw.ed

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