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Towards increasing shelf life and haemostatic potency of stored platelet concentrates

Hegde, Shailajaa; Akbar, Huzoorb,c; Zheng, Yib; Cancelas, Jose A.a,b

doi: 10.1097/MOH.0000000000000456
TRANSFUSION MEDICINE AND IMMUNOHEMATOLOGY: Edited by Steven L. Spitalnik

Purpose of review Platelet transfusion is a widely used therapy in treating or preventing bleeding and haemorrhage in patients with thrombocytopenia or trauma. Compared with the relative ease of platelet transfusion, current practice for the storage of platelets is inefficient, costly and relatively unsafe, with platelets stored at room temperature (RT) for upto 5–7 days.

Recent findings During storage, especially at cold temperatures, platelets undergo progressive and deleterious changes, collectively termed the ‘platelet storage lesion’, which decrease their haemostatic function and posttransfusion survival. Recent progress in understanding platelet activation and host clearance mechanisms is leading to the consideration of both old and novel storage conditions that use refrigeration and/or cryopreservation to overcome various storage lesions and significantly extend platelet shelf-life with a reduced risk of pathogen contamination.

Summary A review of the advantages and disadvantages of alternative methods for platelet storage is presented from both a clinical and biological perspective. It is anticipated that future platelet preservation involving cold, frozen and/or pathogen reduction strategies in a proper platelet additive solution will enable longer term and safer platelet storage.

aHoxworth Blood Center, University of Cincinnati Academic Health Center

bDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati

cDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA

Correspondence to Jose A. Cancelas, MD, PhD, Hoxworth Blood Center, University of Cincinnati Academic Health Center, 3130 Highland Ave, Cincinnati, OH 45267, USA. Tel: +1 513 558 1324; e-mail: Jose.Cancelas@cchmc.org

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