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MicroRNAs in endothelial cell homeostasis and vascular disease

Fernández-Hernando, Carlos; Suárez, Yajaira

Current Opinion in Hematology: May 2018 - Volume 25 - Issue 3 - p 227–236
doi: 10.1097/MOH.0000000000000424
VASCULAR BIOLOGY: Edited by Edward F. Plow

Purpose of review Since the first discovery of microRNAs (miRNAs) in 1993, the involvement of miRNAs in different aspects of vascular disease has emerged as an important research field. In this review, we summarize the fundamental roles of miRNAs in controlling endothelial cell functions and their implication with several aspects of vascular dysfunction.

Recent findings MiRNAs have been found to be critical modulators of endothelial homeostasis. The dysregulation of miRNAs has been linked to endothelial dysfunction and the development and progression of vascular disease which and open new opportunities of using miRNAs as potential therapeutic targets for vascular disease.

Summary Further determination of miRNA regulatory circuits and defining miRNAs-specific target genes remains key to future miRNA-based therapeutic applications toward vascular disease prevention. Many new and unanticipated roles of miRNAs in the control of endothelial functions will assist clinicians and researchers in developing potential therapeutic applications.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence to Yajaira Suárez, PhD, Yale University School of Medicine, 10 Amistad Street, Amistad Research Building 301-B, New Haven, CT 06520, USA. Tel: +1 203 737 8858; fax: +1 203 737 2290; e-mail: yajaira.suarez@yale.edu

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