The purpose of this article is to describe the function of the vascular cell adhesion and signaling molecule, platelet/endothelial cell adhesion molecule-1 (PECAM-1), in endothelial cells, with special emphasis on its role in maintaining and restoring the vascular permeability barrier following disruption of the endothelial cell junction.
In addition to its role as an inhibitory receptor in circulating platelets and leukocytes, PECAM-1 is highly expressed at endothelial cell–cell junctions, where it functions as an adhesive stress-response protein to both maintain endothelial cell junctional integrity and speed restoration of the vascular permeability barrier following inflammatory or thrombotic challenge.
Owing to the unique ability of antibodies that bind the membrane proximal region of the extracellular domain to trigger conformational changes leading to affinity modulation and homophilic adhesion strengthening, PECAM-1 might be an attractive target for treating vascular permeability disorders.
aBlood Research Institute, BloodCenter of Wisconsin
bDepartment of Hematology, Union Hospital, Huazhong University of Science and Technology
cDepartments of Pharmacology
dCell Biology, Neurobiology and Anatomy
eThe Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
*Panida Lertkiatmongkol and Danying Lio are equal co-first authors and contributed equally to the writing of this article.
Correspondence to Peter J. Newman, PhD, Blood Research Institute, BloodCenter of Wisconsin, 638 North 18th Street, Milwaukee, WI 53201, USA. E-mail: email@example.com