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New methods for assessing response in acute myeloid leukemia

Hall, Aric C.; Mattison, Ryan James

Current Opinion in Hematology: March 2015 - Volume 22 - Issue 2 - p 132–138
doi: 10.1097/MOH.0000000000000118
MYELOID DISEASE: Edited by Martin S. Tallman
Editor's Choice

Purpose of review Patients with acute myeloid leukemia typically are monitored with bone marrow biopsy 7–10 days after completion of induction therapy. However, this test has relatively poor sensitivity and specificity for classifying patients likely to have long-term cure or even patients who will need additional therapy to achieve complete remission. Several new methods of assessing response are being studied and are summarized in this review.

Recent findings Many new methods are being used to evaluate response assessment. Emerging data suggest that various types of clinical, chemical, and imaging biomarkers, as well as more sensitive techniques to measure minimal residual disease, can all help provide more accurate response assessment and prognostic information.

Summary New techniques will improve the way we assess response to acute myeloid leukemia therapy. Larger confirmatory studies utilizing these novel markers of response to change treatment and to improve clinical outcomes are urgently needed.

Section of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA

Correspondence to Ryan James Mattison, MD, Assistant Professor of Medicine, Section of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Carbone Comprehensive Cancer Center, 1111 Highland Avenue, 4039 Wisconsin Institutes for Medical Research, Madison, WI 53705-2275, USA. E-mail: rjmattison@medicine.wisc.edu

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