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Detecting fetomaternal hemorrhage by flow cytometry

Dziegiel, Morten Hanefeld; Nielsen, Leif Kofoed; Berkowicz, Adela

doi: 10.1097/01.moh.0000245687.09215.c4
Transfusion medicine

Purpose of review The aim of this review is to summarize the most recent developments in the area of detection of fetomaternal hemorrhage by flow cytometry.

Recent findings Maternal red blood cell chimerism is readily detectable by flow cytometry. Fetal and maternal red blood cells differ in their content of fetal hemoglobin2γ2). Fetal red blood cells contain fetal hemoglobin, and normal maternal red blood cells contain some percentage of fetal hemoglobin in a background of normal adult hemoglobin. All blood group systems with allelic differences between mother and fetus are readily applicable for detection of fetomaternal hemorrhage by fetal hemoglobin.

Summary Fetal hemoglobin for detection of fetomaternal hemorrhage is an accurate clinical diagnostic procedure for investigation of anemia in fetus and newborn.

Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

Correspondence to Morten Hanefeld Dziegiel MD, PhD, H:S Blodbank KI2034, Copenhagen University Hospital (Rigshospitalet), DK-2100 Copenhagen, Denmark Tel: +45 3545 2716; fax: +45 3545 2053; e-mail:

© 2006 Lippincott Williams & Wilkins, Inc.