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Role of interleukin-8 in neutrophil signaling

Zeilhofer, Hanns Ulrich MD; Schorr, Walter MD

Current Opinion in Hematology: May 2000 - Volume 7 - Issue 3 - p 178-182
Hematopoietic growth factors

Interleukin-8 was originally discovered as one of the first chemokines activating neutrophil granulocytes (neutrophils) after secretion by lipopolysaccharide-stimulated monocytes. A wealth of information has been gathered concerning the intracellular events mediated by interleukin-8 and the role of interleukin-8 in numerous physiologic and pathophysiologic processes. We discuss recent advances in the understanding of the initial intracellular signals elicited by interleukin-8. Detailed investigation of these events has led to the identification of subtle but significant differences in the signal transduction processes evoked by interleukin-8 receptors. In particular, much has been learned concerning differences in the cellular mechanisms leading to desensitization, internalization, and recycling of interleukin-8 receptors, and functional consequences of interleukin-8 receptor diversity are now being unraveled.

Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Erlangen, Germany

Correspondence to Hanns Ulrich Zeilhofer, MD, Department of Experimental and Clinical Pharmacology and Toxicology, Fahrstrasse 17, D-91054 Erlangen, Germany; e-mail: zeilhofer@pharmakologie.uni-erlangen.de

© 2000 Lippincott Williams & Wilkins, Inc.