Rumination syndrome when to suspect and how to treatHalland, MagnusCurrent Opinion in Gastroenterology: July 2019 - Volume 35 - Issue 4 - p 387–393 doi: 10.1097/MOG.0000000000000549 ESOPHAGUS: Edited by Stuart J. Spechler Buy Abstract Author InformationAuthors Article MetricsMetrics Purpose of review Rumination syndrome is a gastrointestinal disorder characterized by effortless regurgitation of recently ingested food. The disorder is rare, but likely under-recognized and leads to impaired quality of life among those affected. This review discusses recent studies which examined the pathophysiology, diagnoses and therapy of rumination syndrome. Recent findings The pathogenesis of rumination syndrome remains incompletely understood. Therapeutic options, which appear effective, include behavioral therapy with diaphragmatic breathing and pharmacotherapy with baclofen. A randomized trial of behavioral therapy, biofeedback therapy led to a 74% + /– 6% reduction in rumination activity (from 29 + /– 6 before to 7 + /– 2 daily events after intervention) vs. 1% + /– 14% during sham (from 21 + /– 2 before to 21 + /– 4 daily events after intervention) (P = .001). A recent randomized trial of baclofen at a dose of 10 mg three times daily led to symptomatic improvement in 63% of patients with rumination syndrome. Summary This review summarizes a clinical approach to diagnosing and treating rumination syndrome. Behavioral therapy consisting of diaphragmatic breathing, with or without biofeedback, remains the most effective treatment strategy for patients with rumination syndrome. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Correspondence to Magnus Halland, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st SW Rochester, 55905 MN, USA. E-mail: Halland.email@example.com Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.