INFLAMMATORY BOWEL DISEASE: Edited by Claudio FiocchiThe mesentery in Crohn's disease friend or foe?Coffey, John Calvin; O‘Leary, Donal Peter; Kiernan, Miranda G.; Faul, PeterAuthor Information aDepartment of Surgery, University Hospital Limerick bGraduate Entry Medical School, University of Limerick c4I Centre for Interventions in Infection, Inflammation and Immunity, University of Limerick dDepartment of Pathology, University Hospital Limerick, Limerick, Ireland Correspondence to Professor J. Calvin Coffey, PhD, FRCSI, Surgical Professorial Unit, University Hospital Limerick, Limerick, Ireland. Tel: +353 61 482412; fax: +353 61 482410; e-mail: [email protected] Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-gastroenterology.com). Current Opinion in Gastroenterology: July 2016 - Volume 32 - Issue 4 - p 267-273 doi: 10.1097/MOG.0000000000000280 Buy SDC Metrics Abstract Purpose of review This article assesses the role of the mesentery in Crohn's disease. Recent findings The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. Summary The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. https://links.lww.com/COG/A18. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.