The mesentery in Crohn's disease: friend or foe? : Current Opinion in Gastroenterology

Secondary Logo

Journal Logo

INFLAMMATORY BOWEL DISEASE: Edited by Claudio Fiocchi

The mesentery in Crohn's disease

friend or foe?

Coffey, John Calvin; O‘Leary, Donal Peter; Kiernan, Miranda G.; Faul, Peter

Author Information
Current Opinion in Gastroenterology 32(4):p 267-273, July 2016. | DOI: 10.1097/MOG.0000000000000280

Abstract

Purpose of review 

This article assesses the role of the mesentery in Crohn's disease.

Recent findings 

The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence.

Summary 

The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means.

https://links.lww.com/COG/A18.

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

You can read the full text of this article if you:

Access through Ovid