STOMACH AND DUODENUM: Edited by Mitchell L. Schubert and Tilak U. ShahManagement of Helicobacter pyloriArgueta, Erick A.; Moss, Steven F. Author Information Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA Correspondence to Steven F. Moss, MD, AGAF, FACG, Professor of Medicine, Division of Gastroenterology, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA. Tel: +1 401 444 5679; fax: +1 401 444 8751; e-mail: [email protected] Current Opinion in Gastroenterology: November 2020 - Volume 36 - Issue 6 - p 518-524 doi: 10.1097/MOG.0000000000000678 Buy Metrics Abstract Purpose of review Gastroenterologists and many general internists and primary care physicians confront questions regarding the management of Helicobacter pylori on a daily basis. The subject remains of global interest and continue to generate debate and research. Using the search terms ‘pylori and treatment’ or ‘pylori and management’ we identified over 1000 relevant articles in PubMed published over the time period 1 January 2019 to 30 April 2020. We have selected the most highly clinically relevant of these to review here. Recent findings Clinical evidence grows regarding the benefits of H. pylori eradication on gastric cancer prevention. High rates of resistance to clarithromycin and levofloxacin, correlating with treatment failure in regimens utilizing these drugs, has stimulated interest in alternative regimens as well as the need for susceptibility testing of individual patients and populations. Although many aspects of H. pylori management are well established, implementation of appropriate testing and treatment pathways remains suboptimal throughout healthcare settings. Summary Increased emphasis on measuring H. pylori-related clinical outcomes in practice is needed to identify implementation gaps, and to suggest means to best apply the knowledge gained on H. pylori for the prevention of gastric symptoms and disease. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.