ENDOSCOPY: Edited by Anthony N. KallooEndoscopic techniques for myotomy of the lower esophageal sphincter and pylorusParsa, Nasima; Khashab, Mouen A.bAuthor Information aDivision of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri bDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, USA Correspondence to Mouen A. Khashab, MD, Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans Street, Zayed Building, Suite 7125B, Baltimore, MD 21287, USA. Fax: +1 443 683 8335; e-mail: email@example.com Current Opinion in Gastroenterology: September 2019 - Volume 35 - Issue 5 - p 416-423 doi: 10.1097/MOG.0000000000000560 Buy Metrics Abstract Purpose of review Peroral endoscopic myotomy (POEM) and gastric peroral endoscopic myotomy (G-POEM) are minimally invasive endoscopic procedures for the treatment of esophageal motility disorders and refractory gastroparesis, respectively. In this review, we highlight the most recent publications on the technical aspects of POEM and G-POEM. Recent findings POEM has evolved into a standard therapeutic option in patients with all achalasia subtypes with excellent durability and safety profile. G-POEM is a novel endoscopic procedure with promising results in terms of efficacy, safety, and symptom improvement in patients with refractory gastroparesis. Summary POEM and G-POEM are novel endoscopic procedures. Practice patterns vary among endoscopists and procedure techniques continue to evolve. Comparative studies examining outcomes of different techniques are needed. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.