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Functional dyspepsia and gastroparesis

Tack, Jan; Carbone, Florencia

Current Opinion in Gastroenterology: November 2017 - Volume 33 - Issue 6 - p 446–454
doi: 10.1097/MOG.0000000000000393
STOMACH AND DUODENUM: Edited by Mitchell L. Schubert
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Purpose of review This review summarizes recent progress in the epidemiology, pathophysiology and treatment of functional dyspepsia and gastroparesis.

Recent findings The definition of functional dyspepsia and its subgroups has been revised in the recent Rome IV consensus. In gastroparesis, the symptom pattern and its similarities and differences from functional dyspepsia have been a focus of recent research. In functional dyspepsia, pathophysiological research continued to evaluate gastric sensorimotor dysfunctions, but low-grade inflammatory changes and loss of mucosal integrity in the duodenum is a new topic of intense research. Treatment advances include new prokinetics such as acotiamide and the ghrelin receptor agonist relamorelin. The efficacy of tricyclic antidepressants was recently reviewed and mirtazapine is a new agent used in the treatment of functional dyspepsia and gastroparesis. In gastroparesis, research has focused on the role of macrophages in loss of interstitial cells of Cajal, and on the role of pyloric resistance as a target for therapy, using botulinum toxin injection and gastric per-endoscopic pyloric myotomy.

Summary The functional dyspepsia definition and subgrouping were updated in the Rome IV consensus. Research focuses on duodenal mucosal alterations in functional dyspepsia and pyloric resistance in gastroparesis. New treatments include novel prokinetics and pylorus-directed interventions.

Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, University Hospital Gasthuisberg, Leuven, Belgium

Correspondence to Jan Tack, Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, University Hospital Gasthuisberg, O&N I – bus 701, Herestraat 49, B-3000 Leuven, Belgium. Tel: +32 16 34 42 25; fax: +32 16 34 44 19; e-mail: jan.tack@med.kuleuven.ac.be

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