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Nutritional consequences of long-term acid suppression; are they clinically important?

Johnson, David A.

Current Opinion in Gastroenterology: March 2016 - Volume 32 - Issue 2 - p 136–140
doi: 10.1097/MOG.0000000000000250
NUTRITION: Edited by Eamonn M.M. Quigley

Purpose of review As acid suppression therapies with proton pump inhibitors are an extremely common practice for common acid-related diseases, there has been increased scrutiny on the safety of this class of therapy.

Recent findings There have been increasing reports of allegation of harm with the sustained use of proton pump inhibitors, in particular with potential adverse effects on vitamin and mineral absorption. This has prompted a number of product label changes directed by the US Food and Drug Administration, raising concerns for ongoing continued use among clinicians and patients.

Summary This review highlights the most recent information around these controversies and provides evidence summaries to help guide care providers in their care plans as well as discussions with patients.

Department of Medicine/Gastroenterology, Eastern VA Medical School, Norfolk, Virginia, USA

Correspondence to David A. Johnson, MD, MACG, FASGE, FACP, Department of Medicine/Gastroenterology, Eastern VA Medical School, 885 Kempsville Rd Suite 114, Norfolk, VA 23502, USA. Tel: +1 757 466 0165; e-mail:

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