Gastrointestinal infections: Edited by Mitchell CohenGastric acidity inhibitors and the risk of intestinal infectionsBerni Canani, Robertoa,b; Terrin, Gianlucaa Author Information aDepartment of Pediatrics, Italy bEuropean Laboratory for the Investigation on Food Induced Diseases University ‘Federico II’ of Naples, Naples, Italy Correspondence to Roberto Berni Canani, MD, PhD, Department of Pediatrics, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy Tel/fax: +39 0817462680; e-mail: [email protected] Current Opinion in Gastroenterology: January 2010 - Volume 26 - Issue 1 - p 31-35 doi: 10.1097/MOG.0b013e328333d781 Buy Metrics Abstract Purpose of review We reviewed recent clinical studies performed in adults, children, and neonates exploring the possible association of gastric acidity inhibitors use with intestinal infections. Possible mechanisms have also been reported. Recent findings Many studies and systematic reviews demonstrate an increased risk of bacterial infection in adults taking acid suppressors. Little evidence is derived from the pediatric population. The use of gastric acidity inhibitors has been associated with systemic infections and necrotizing enterocolitis in preterm infants. Reduced gastric acidity, delayed gastric emptying, increased gastric mucus viscosity, modification in microbiota, and impairment of neutrophils functions, are all conditions determined by gastric acidity blockers that potentially lead to an increased risk of gastrointestinal infections. Summary A proper utilization of these drugs, particularly for patients at high risk, is imperative in order to reduce deleterious effects on infection risk and to optimize cost-effectiveness ratio. © 2010 Lippincott Williams & Wilkins, Inc.