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Pathogenesis of Campylobacter

Poly, Frédéric; Guerry, Patricia

Current Opinion in Gastroenterology: January 2008 - Volume 24 - Issue 1 - p 27–31
doi: 10.1097/MOG.0b013e3282f1dcb1
Gastrointestinal infections: Edited by Edgar C. Boedeker
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Purpose of review Molecular pathogenesis of Campylobacter jejuni has lagged behind that of other enteric pathogens. This review summarizes advances in the biology and pathogenesis of C. jejuni.

Recent findings Multiple genome sequences have defined conserved and hypervariable loci in the C. jejuni genome. Interaction of C. jejuni with eukaryotic cells results in numerous signal transduction changes and release of proinflammatory cytokines. In-vivo models based on immune knockout mice have also revealed new information on pathogenesis.

Summary New information and new methods are available that should provide important tools to further understand pathogenesis of this elusive pathogen.

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA

Correspondence to Patricia Guerry, PhD, Enteric Diseases Dept., Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA Tel: +1 301 319 7662; fax: +1 301 319 7679; e-mail: patricia.guerry@mod.navy.mil

© 2008 Lippincott Williams & Wilkins, Inc.