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Cholestatic syndromes

Trauner, Michaela; Boyer, James L.b

Current Opinion in Gastroenterology: May 2004 - Volume 20 - Issue 3 - p 220-230

Purpose of review This review highlights recent developments in the molecular pathogenesis of cholestasis as well new aspects of pathogenesis and management of clinical cholestatic disorders.

Recent findings Highlights include the role of nuclear receptors including FXR ligands as potential therapeutic agents, new genetic defects for pediatric cholestasis and sclerosing cholangitis, and novel infections and environmental agents as etiologies for primary biliary cirrhosis. Important clinical studies have been published in the area of pediatric cholestatic syndromes, intrahepatic cholestasis of pregnancy, primary biliary cirrhosis, primary and secondary sclerosing cholangitis, cholestasis of sepsis, viral cholestatic syndromes, and drug-induced cholestasis.

Summary These advances continue to improve understanding of the pathophysiology, diagnosis, and management of cholestatic liver disease.

aDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Austria and bDepartment of Medicine and Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence to James L. Boyer, MD, Yale University School of Medicine, P.O. Box 208019, 333 Cedar Street, New Haven, CT 06529-8019, USA

Tel: 203 785 5279; fax: 203 785 5279; e-mail:

© 2004 Lippincott Williams & Wilkins, Inc.